Our Team

Dr. Seymour is Assistant Professor of Critical Care and Emergency Medicine at the University of Pittsburgh School of Medicine. He is core faculty member in the Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center in the Department of Critical Care, where he contributes to the Program on Critical Care Health Policy. He is affiliated faculty in the Center for Research on Emergency Medical Services (CREMS) in the Center for Emergency Medical Services of Western Pennsylvania.

Dr. Seymour's research program focuses on the organization of critical care during pre-hospital care - particularly the development of early diagnostic and prognostic models to facilitate allocation of patients and early treatments for those with acute illness.

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Vincent Liu is an intensivist and research scientist at the Kaiser Permanente Division of Research; he is also a Clinical Assistant Professor of Medicine (Affiliated) at Stanford University. As a current K scholar studying 'Data-driven precision medicine in sepsis' his work focuses on applying health services and biomedical informatics methods to granular clinical data to foster the development of the learning hospital system.

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I am a critical care physician and health services researcher, working at the University of Michigan and VA Ann Arbor Health System. My roles include Associate Professor, co-Director of the National Clinician Scholars Program, and Faculty Associate of the Survey Research Center. Broadly I am interested in using advanced quantitative techniques to understand how critical illness affects the arc of patients' lives, and how to improve recovery from critical illness.

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Frank M. Brunkhorst is Consulting Physician for Internal Medicine and Medical Intensive Care Medicine. He holds a Full Professorship for Clinical Sepsis Research at Jena University Hospital. Since 6/2013 is Director of the Center for Clinical Studies at Jena University Hospital. Since 2008 is Chairman of the self-help group German Sepsis Aid (GSA)and since 2001 General Manager and national guideline coordinator of the German Sepsis-Society (GSS). In 2005 he has been awarded the German Federal Cross of Merit by the President of the Federal Republic of Germany for research excellence in the field of severe infections and sepsis.

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Dr. Rea is a Professor of Medicine at the University of Washington, Section Head at Harborview Medical Center, and Program Medical Director for King County Medic One Emergency Medical Services. He completed his MD at the University of Michigan School of Medicine in 1992 and his MPH at the University of Washington School of Public Health in 2000. His research interests include the factors influencing risk and outcome of cardiac arrest, pharmacoepidemiology, and prehospital emergency care.

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André Scherag is Professor of Clinical Epidemiology at the Center of Sepsis Control and Care (CSCC; Jena University Hospital; Jena; Germany). After graduating Psychology and Biostatistics and a PhD in Biostatistics, AS lead a research group "Bioinformatics and Biometry." He is interested in methodological questions arising in the translational gaps between basic and clinical science including questions of precision medicine, adaptive / flexible designs, statistical genomics / genetic epidemiology / bioinformatics, big data issues and the implementation of new results in health services.

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Gordon Rubenfeld is the inaugural Chief of the Program in Trauma, Emergency, and Critical Care at Sunnybrook Health Sciences Centre and Professor of Medicine at the University of Toronto. He serves on the editorial boards of the American Journal of Respiratory and Critical Care Medicine, Respiratory Care, the Journal of Critical Care, Critical Care, and Lancet-Respiratory Medicine.

Dr. Rubenfeld's research focuses on the clinical epidemiology and outcomes of critical illness syndromes, the transfer of evidence into clinical practice, and end-of-life care issues in the ICU. Ongoing projects include a cluster randomized trial of interventions to increase use of lung protective ventilation in patients with acute lung injury and a randomized trial to improve long-term outcomes in survivors of prolonged mechanical ventilation.

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Dr. Kahn is Professor of Critical Care, Medicine and Health Policy in the University of Pittsburgh School of Medicine and Graduate School of Public Health. He is a core faculty member in the CRISMA Center in the Department of Critical Care Medicine, where he directs the CRISMA Program on Critical Care Health Policy & Management.

Dr. Kahn's research program focuses on the organization, management, and financing of critical care services. Specific areas of interest include ICU workforce and staffing, quality measurement, benchmarking, and regionalization of critical care. His group's work integrates approaches from the fields of epidemiology, health services research, health economics and operations management to investigate novel strategies for increasing the quality and efficiency of critical care.

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Dr Manu Shankar-Hari joined Guy's and St Thomas' critical care team as a consultant physician and clinician researcher in 2009.

He is the chairman of the Sepsis Quality Improvement Project in the hospital.

Manu's research focuses on lymphocyte biology and epidemiology of sepsis.

His immunology research explores the acute changes in immunoglobulin molecules, free light chains and lymphocyte abnormalities in sepsis related critical illness.

His epidemiology research explores the reasons for international variations in sepsis epidemiology, ways to improve septic shock definitions and the determinants of long-term mortality in acute illness survivors.

Manu has been a faculty teaching performing observational research course at the NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London since 2011.

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Mervyn Singer is Professor of Intensive Care Medicine at University College London. His primary research interests are sepsis and multi-organ failure, infection, shock and haemodynamic monitoring. Funding for these activities primarily comes from the Wellcome Trust, Medical Research Council and National Institute for Health Research. He developed an oesophageal Doppler haemodynamic monitor that is now in widespread use worldwide, the use of which has been shown in multiple studies to improve outcomes after major surgery and reduce length of stay. He has led on a number of important multi-centre trials in critical care. He has authored various papers and textbooks including the Oxford Handbook of Critical Care, now in its 3rd Edition, and is a Council member of the International Sepsis Forum.

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Dr. Deutschman is the Vice Chair of Research in the Department of Pediatrics and Professor of Pediatrics and Molecular Medicine at Hofstra-Northwell School of Medicine. He also serves as a Senior Investigator at the Feinstein Institute for Medical Research. Additionally, Dr. Deutschman spent 20 years working in the SICU at the Hospital of the University of Pennsylvania, and served as SCCM President in 2012.

Dr. Deutschman's long-term bench/translational sepsis investigator focus is on sepsis-induced disruption of brain modulation of inflammation, mitochondrial dysfunction, cellular signal transduction - cytokines, glucocorticoids, and organ dysfunction.

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Dr. Escobar is a research scientist at the Kaiser Permanente Division of Research and also serves as the Regional Director for Hospital Operations Research for Kaiser Permanente's Northern California Region. A health services researcher, his research focuses on the outcomes of hospitalized adults, predictive analytics, and informatics.

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Dr. Angus is Professor and Chair of the Department of Critical Care Medicine and Director of CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illnesses) Center at the University of Pittsburgh. He holds secondary appointments in Medicine, Health Policy and Management, and Clinical and Translational Science.

Dr. Angus' research interests include clinical, epidemiologic and translational studies of sepsis, pneumonia, and multisystem organ failure and health services research of the organization and delivery of critical care services. Dr. Angus has published several hundred papers, reviews, and book chapters, is currently section editor for "Caring for the Critically Ill" for JAMA, and is the recipient of numerous awards, including the 2009 American College of Critical Care Medicine Distinguished Investigator Award.

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